Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Jeroen R HuygheTabitha A HarrisonStephanie A BienHeather HampelJane C FigueiredoStephanie L SchmitDavid V ContiSai ChenConghui QuYi LinRichard BarfieldJohn A BaronAmanda J CrossBrenda DiergaardeDavid DugganSophia HarlidLiher ImazHyun Min KangDavid M LevineVittorio PerducaAurora Perez-CornagoLori C SakodaFredrick R SchumacherMartha L SlatteryAmanda E TolandFränzel J B van DuijnhovenBethany Van GuelpenAntonio AgudoDemetrius AlbanesM Henar AlonsoKristin AndersonCoral Arnau-CollellVolker ArndtBarbara L BanburyMichael C BassikSonja I BerndtStéphane BézieauD Timothy BishopJuergen BoehmHeiner BoeingMarie-Christine Boutron-RuaultHermann BrennerStefanie BrezinaStephan BuchDaniel D BuchananAndrea Burnett-HartmanBette J CaanPeter T CampbellPrudence R CarrAntoni CastellsSergi Castellví-BelAndrew T ChanJenny Chang-ClaudeStephen J ChanockKeith R CurtisAlbert de la ChapelleDouglas F EastonDallas R EnglishEdith J M FeskensManish GalaSteven J GallingerW James GaudermanGraham G GilesPhyllis J GoodmanWilliam M GradyJohn S GroveAndrea GsurMarc J GunterRobert W HaileJochen HampeMichael HoffmeisterJohn L HopperWan-Ling HsuWen-Yi HuangThomas J HudsonMazda JenabMark A JenkinsAmit D JoshiTemitope O KekuCharles KooperbergTilman KühnSébastien KüryLoic Le MarchandFlavio LejbkowiczChristopher I LiLi LiWolfgang LiebAnnika LindblomNoralane M LindorSatu MännistöSanford D MarkowitzRoger L MilneLorena MorenoNeil MurphyRami NassirKenneth OffitShuji OginoSalvatore PanicoPatrick S ParfreyRachel PearlmanPaul D P PharoahAmanda I PhippsElizabeth A PlatzJohn D PotterRoss L PrenticeLihong QiLeon RaskinGad RennertHedy S RennertElio RiboliClemens SchafmayerRobert E SchoenDaniela SeminaraMingyang SongYu-Ru SuCatherine M TangenStephen N ThibodeauDuncan C ThomasAntonia TrichopoulouCornelia M UlrichKala VisvanathanPavel VodickaLudmila VodickovaVeronika VymetalkovaKorbinian WeiglStephanie J WeinsteinEmily WhiteAlicja WolkMichael O WoodsAnna H WuGoncalo R AbecasisDeborah A NickersonPeter C ScacheriAnshul KundajeGraham CaseyStephen B GruberLi HsuVictor MorenoRichard B HayesPolly A NewcombUlrike PetersPublished in: Gut (2021)
Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.