Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation.
Jie SuPierre ColemanAngeliki NtorlaRhys AndersonMichael J ShattockJoseph Robert BurgoynePublished in: Circulation (2023)
The activation of PKGI by cGAMP enables the coupling of blood pressure to cytosolic DNA sensing by cGAS, which plays a key role during sepsis by mediating hypotension and tissue hypoperfusion.