17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze.
Kristina LaubhahnAndreas BöckKathrin ZeberSandra UnterschemmannSonja KunzeMichaela SchedelBianca SchaubPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
Locus-dependent eQTL SNPs (core region) associated with increased inflammatory genes (primarily TLR2) at birth and subsequent multitrigger wheeze indicate that early priming and imbalance may be crucial for asthma pathophysiology. Locus-independent eQTL SNPs (mainly distal region, rs1007654) may be involved in the initiation of dendritic cell activation/maturation (TRAF6) and interaction with T cells (CD209, CD86). Identifying potential mechanistic pathways at birth may point to critical key points during early immune development predisposing to asthma.
Keyphrases
- cord blood
- genome wide
- dendritic cells
- chronic obstructive pulmonary disease
- lung function
- gestational age
- copy number
- allergic rhinitis
- immune response
- dna methylation
- toll like receptor
- inflammatory response
- genome wide association study
- regulatory t cells
- oxidative stress
- minimally invasive
- genome wide association
- pregnancy outcomes
- gene expression
- bioinformatics analysis
- nuclear factor
- risk assessment
- preterm birth