Protective effect of Pureraia lobata leaves on doxorubicin induced myocardial infarction in experimental Wistar rats.

The present study intended to explore the preventive effects of Pureraia lobata (P.lobata) leaves against doxorubicin (DOX) induced myocardial infarction (MI) in Wistar rats. The rats were separated into four groups, with each group containing six rats. Group-I control rats; Group-II received DOX-alone in six equivalent injection for two-weeks; Group-III received DOX as above-mentioned with P.lobata oral administration for two-weeks; Group-IV received P.lobata alone for two-weeks. At the end of the experiment,postcervical dislocation and MI induced by DOX was determined on the basis of the variations in the animal body and heart weight, and further instabilities in cardiac marker enzymes AST, LDH, CK, CK-MB, and cTnI in the serum. At the same time, for Group-III animals, which were exposed to P.lobata, all the above denoted marker levels were maintained. Levels of some crucial heart binding proteins like H-FABP, MCP-1, TGF-β were elevated in DOX-alone treated rats. Additionally, Group-III animals treated with P.lobata showed some preventive down-regulated expressions of these binding proteins. Histopathological observations also revealed the preventive effect of P.lobata.Ultimately proteins tangled in PI3K/Akt pathway were studied by Western blot. P.lobata treatment down-regulated the inflammatory markers. The findings suggest that P.lobata exhibits cardioprotective effecton MI. This article is protected by copyright. All rights reserved.