Low-frequency coding variants associated with body-mass-index impact the success of bariatric surgery.

Darlène AntoineRosa-Maria Guéant-RodriguezJean-Claude ChèvreSébastien HergalantTanmay SharmaZhen LiPierre RouyerCéline CherySarah HalvickCatherine BuiAbderrahim OussalahOlivier ZieglerDidier QuilliotLaurent BrunaudJean-Louis GuéantDavid Meyre

Published in: The Journal of clinical endocrinology and metabolism (2021)

Our data indicate that in populations of European descent, low-frequency coding variants associated with BMI in the general population also impact the outcomes of bariatric surgery in patients with severe/morbid obesity.

Keyphrases

bariatric surgery
weight loss
body mass index
obese patients
weight gain
copy number
metabolic syndrome
type diabetes
insulin resistance
electronic health record
physical activity
gene expression
adipose tissue
skeletal muscle
dna methylation
big data
genetic diversity
data analysis