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SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.

Volodymyr GerzanichMin Seong KwonSeung Kyoon WooAlexander IvanovJ Marc Simard
Published in: PloS one (2018)
tPA induces PAR1-mediated, SUR1-TRPM4-dependent, phasic secretion of MMP-9 from activated brain endothelium.
Keyphrases
  • endothelial cells
  • resting state
  • white matter
  • functional connectivity
  • nitric oxide
  • cell migration
  • cerebral ischemia
  • multiple sclerosis
  • brain injury
  • subarachnoid hemorrhage