Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine.

Matthias KarerMarlene Rager-ReschTeresa HaiderKarin PetrocziElisabeth GludovaczNicole BorthBernd JilmaThomas Boehm

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)

Inactivation of exogenous histamine is not driven by enzymatic degradation and kidney filtration. Treatment with recombinant human DAO strongly reduced histamine-induced core body temperature loss, histamine concentrations and prevented the development of severe clinical symptoms.

Keyphrases

recombinant human
high glucose
early onset
hydrogen peroxide
diabetic rats
sleep quality
combination therapy