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Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine.

Matthias KarerMarlene Rager-ReschTeresa HaiderKarin PetrocziElisabeth GludovaczNicole BorthBernd JilmaThomas Boehm
Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)
Inactivation of exogenous histamine is not driven by enzymatic degradation and kidney filtration. Treatment with recombinant human DAO strongly reduced histamine-induced core body temperature loss, histamine concentrations and prevented the development of severe clinical symptoms.
Keyphrases
  • recombinant human
  • high glucose
  • early onset
  • hydrogen peroxide
  • diabetic rats
  • sleep quality
  • combination therapy