Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis.

Wei ZhangLei Le ZhangShuo YangBin WenJuan ChenJun Chang

Published in: Molecular pain (2022)

The results indicate that EA can inhibit NLRP3 inflammasome and reduce pyroptosis, which results in the protection of cartilage tissue and the treatment of KOA. It provides reliable evidence for the development of EA in the treatment of KOA and the clinical application of acupuncture.

Keyphrases

nlrp inflammasome
knee osteoarthritis
signaling pathway
mouse model
spinal cord
neuropathic pain
combination therapy
cerebral ischemia