Perioperative Systemic Chemotherapy for Colorectal Liver Metastasis: Recent Updates.
Hee Yeon LeeIn Sook WooPublished in: Cancers (2021)
The liver is the most common site of metastases for colorectal cancer. Complete resection in some patients with resectable liver metastases (LM) can lead to long-term survival and cure. Adjuvant systemic chemotherapy after complete resection of LM improves recurrence-free survival; however, the overall survival benefit is not clear. In selected patients, preoperative systemic treatment for metastatic colorectal cancer can convert unresectable to resectable cancer. This review will focus on patient selection, and integration of perioperative and postoperative systemic treatment to surgery in resectable and initially unresectable LM. Additionally, new drugs and biomarkers will be discussed.
Keyphrases
- liver metastases
- locally advanced
- free survival
- patients undergoing
- rectal cancer
- metastatic colorectal cancer
- end stage renal disease
- squamous cell carcinoma
- cardiac surgery
- radiation therapy
- minimally invasive
- newly diagnosed
- early stage
- chronic kidney disease
- prognostic factors
- coronary artery disease
- peritoneal dialysis
- case report
- drug induced
- combination therapy
- patient reported outcomes
- coronary artery bypass
- atrial fibrillation
- acute kidney injury
- percutaneous coronary intervention
- replacement therapy
- lymph node metastasis