Mortality in the first six months among HIV-positive and HIV-negative patients empirically treated for tuberculosis.
Helena HuergaGabriella FerlazzoStephen WanjalaMathieu BastardPaolo BevilacquaElisa ArdizzoniJoseph SitieneiMaryline BonnetPublished in: BMC infectious diseases (2019)
Our findings suggest that in a context with access to Xpert, clinicians should continue using empirical TB treatment in HIV-positive patients with signs and symptoms of TB and negative Xpert results. However, differential diagnoses other than TB should be actively sought before initiating empirical TB treatment, particularly in HIV-negative patients.
Keyphrases
- hiv positive
- antiretroviral therapy
- men who have sex with men
- south africa
- mycobacterium tuberculosis
- hiv testing
- human immunodeficiency virus
- hiv infected
- ejection fraction
- hiv aids
- hepatitis c virus
- type diabetes
- emergency department
- cardiovascular events
- patient reported outcomes
- smoking cessation
- risk factors
- electronic health record
- combination therapy