Examination of rare genetic variants in dental enamel genes: The potential role of next-generation sequencing in primary dental care.
Emily G FarrowShankar Rengasamy VenugopalanIsabelle ThiffaultCarol SaundersPublished in: Orthodontics & craniofacial research (2019)
The rapid integration of NGS into clinical care allows for the expansion of genetic testing for disorders that are not currently tested routinely, including non-syndromic dental enamel disorders. A genotypic-driven diagnosis of a disorder of enamel development could impact dental care, especially in young children, including early and more frequent monitoring to prevent complications. As new gene-disease associations continue to emerge, including those for common and non-syndromic craniofacial disorders, the possibility of genomic-guided precision medicine and dentistry and the development of targeted, individualized therapeutics into standard clinical care will increase substantially.