PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma.
Guannan ShuMinyu ChenWuyuan LiaoLiang-Min FuMingjie LinCheng-Peng GuiJunjie CenJun LuZhen-Hua ChenJin-Huan WeiWei ChenYing-Han WangJiangquan ZhuTianxin ZhaoXiao-Nan LiuJiajia JingGuo-Chang LiuYihui PanJunhang LuoJiaxing ZhangPublished in: Cancer research (2024)
PABPC1L functions as a key factor in renal cell carcinoma immune evasion, enhancing IDO1 and impeding T-cell function, and represents a potential target to enhance the efficacy of immune checkpoint blockade therapy.