A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate.

Kathleen F PirolloManish MogheMiaoyin GuanAntonina S RaitAibing WangSang-Soo KimEsther H ChangJoe B Harford

Published in: International journal of nanomedicine (2024)

Our data indicate that scL-2PAM is superior to the currently used form of 2-PAM in terms of both mitigating paraoxon toxicity in mice and reactivating acetylcholinesterase in their brains.

Keyphrases

high fat diet induced
oxidative stress
electronic health record
white matter
cancer therapy
resting state
big data
adipose tissue
machine learning
multiple sclerosis
functional connectivity
deep learning