Lynch syndrome associated endometrial carcinomas in Western Australia: an analysis of universal screening by mismatch repair protein immunohistochemistry.

Surabhi GuptaCassandra B NicholsJessica PhillipsSarah O'SullivanChloe AyresGanendra Raj MohanYee LeungColin J R StewartAdeline TanLyn SchofieldStuart G SalfingerCatherine Kiraly-BorriNicholas PachterPaul Andrew Cohen

Published in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2021)

Universal immunohistochemical screening did not increase the proportion of Lynch syndrome associated endometrial carcinomas identified, although the study was underpowered to detect small differences. There was an improvement in appropriate referrals for genetic assessment.

Keyphrases

high grade
endometrial cancer
case report
south africa
genome wide
gene expression
protein protein
small molecule
binding protein