CDK9: A key player in cancer and other diseases.
Lia Carolina FrancoFatima MoralesSilvia BoffoAntonio GiordanoPublished in: Journal of cellular biochemistry (2017)
Cyclin-Dependent Kinase 9 (CDK9) is part of a functional diverse group of enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin T1 and forms the Positive Transcription Elongation Factor b (p-TEFb) complex responsible for regulation of transcription elongation and mRNA maturation. Recent studies have highlighted the importance of CDK9 in many relevant pathologic processes, like cancer, cardiovascular diseases, and viral replication. Herein we provide an overview of the different pathways in which CDK9 is directly and indirectly involved.
Keyphrases
- cell cycle
- cell proliferation
- papillary thyroid
- cardiovascular disease
- squamous cell
- transcription factor
- sars cov
- lymph node metastasis
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- childhood cancer
- metabolic syndrome
- type diabetes
- coronary artery disease
- signaling pathway
- locally advanced
- rectal cancer
- case control