Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.

Kawita M S KanhaiR G J A ZuikerI StavrakakiW GladdinesP J GaillardE S KlaassenG J Groeneveld

Published in: British journal of clinical pharmacology (2018)

2B3-201 is considered safe, with no clinically relevant changes in central nervous system safety parameters and no serious adverse events. In addition, 2B3-201 shows a long plasma half-life and prolonged immunosuppressive effects.

Keyphrases

high dose
endothelial cells
induced pluripotent stem cells
peripheral blood
low dose
physical activity
recombinant human