Expanding the Spectrum of Diabetic Striatopathy: Insights from a Case of Hyperglycemia-Induced Propriospinal Myoclonus.
Debaleena MukherjeeSubhankar ChatterjeePeyalee SarkarRitwik GhoshShambaditya DasBiman Kanti RayAlak PanditJulián Benito-LeónSouvik DubeyPublished in: Tremor and other hyperkinetic movements (New York, N.Y.) (2023)
This video abstract delves into the expanded definition of diabetic striatopathy, linked initially to hyperglycemia-induced choreoballism and striatal hyperintensity on magnetic resonance imaging, but now recognized to encompass a broader range of acute onset, non-choreoballistic movement disorders in diabetes mellitus, including tremors, hemifacial spasm, parkinsonism, different types of myoclonus, dystonia, restless leg syndrome, ataxia, and dyskinesias. We report the case of a 45-year-old female patient with type-2 diabetes mellitus who developed propriospinal myoclonus, characterized by painless, involuntary jerky movements of the bilateral lower limbs in a supine position after admission for suspected rhino-orbital mucormycosis. The abnormal movements resolved entirely following the control of her blood glucose levels, suggesting a direct correlation between hyperglycemia and the clinical picture. This case highlights the importance of considering a wide range of differential diagnoses for abnormal lower limb movements in diabetic patients, emphasizing the need for accurate identification of movement semiology, routine bedside capillary blood glucose checks, and prompt hyperglycemia management to resolve such movement disorders effectively.
Keyphrases
- blood glucose
- diabetic rats
- glycemic control
- lower limb
- oxidative stress
- drug induced
- magnetic resonance imaging
- type diabetes
- case report
- high glucose
- blood pressure
- early onset
- emergency department
- high resolution
- wound healing
- computed tomography
- weight loss
- contrast enhanced
- metabolic syndrome
- functional connectivity
- skeletal muscle
- extracorporeal membrane oxygenation
- mass spectrometry