Preventive CTLA-4-Ig Treatment Reduces Hepatic Egg Load and Hepatic Fibrosis in Schistosoma mansoni-Infected Mice.

Martina SombetzkiAnne RabesMiriam BischofsbergerFranziska WinkelmannNicole KoslowskiCindy SchulzEmil C Reisinger

Published in: BioMed research international (2019)

We could demonstrate that an early preventive administration of CTLA-4-Ig suppresses effector T cell function and therefore ameliorates liver fibrosis. CTLA-4-Ig administration after onset of egg production fails to treat hepatic fibrosis.

Keyphrases

liver fibrosis
signaling pathway
mouse model
type diabetes
high fat diet induced
insulin resistance
replacement therapy
type iii