Studying host genetic background effects on multimorbidity of intestinal cancer development, type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross (CC) lines.

Asal MilhemHanifa J Abu Toamih-AtamniLuna KarkarYael Houri-HaddadFuad A Iraqi

Published in: Animal models and experimental medicine (2021)

The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance, and this effect is gender related.

Keyphrases

high fat diet
insulin resistance
high fat diet induced
type diabetes
adipose tissue
metabolic syndrome
genome wide
skeletal muscle
papillary thyroid
glycemic control
mental health
copy number
dna methylation
quality improvement
physical activity
drug induced