MLCK-mediated intestinal permeability promotes immune activation and visceral hypersensitivity in PI-IBS mice.

Y LongLijun Du John J Kim B ChenY ZhuY ZhangS YaoH HeX ZhengZhihui Huang Ning Dai

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

MLCK is a pivotal step in inducing increased intestinal permeability promoting low-grade intestinal immune activation and visceral hypersensitivity in PI-IBS mice. MLCK inhibitor may provide a potential therapeutic option in the treatment of IBS.

Keyphrases

low grade
irritable bowel syndrome
high grade
high fat diet induced
insulin resistance
endothelial cells
drug induced
type diabetes
skeletal muscle
metabolic syndrome