Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Xingnan LiStefano GuerraJulie G LedfordMonica KraftHuashi LiAnnette T HastieMario CastroLoren C DenlingerSerpil C ErzurumJohn V FahyBenjamin GastonElliot IsraelNizar N JarjourBruce David LevyDavid T MaugerWendy C MooreJoe ZeinNaftali KaminskiSally E WentzelPrescott G WoodruffDeborah A MeyersEugene R Bleeckernull nullPublished in: American journal of respiratory and critical care medicine (2022)
Our findings indicate that low CC16 mRNA expression levels in BEC are associated with asthma susceptibility, severity, and exacerbations, partially through immunomodulation of T2 inflammation. CC16 is a potential non-T2 biomarker for asthma development and progression.