A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow.

Xin-Jie LinChien-Lung Wang Chi-How Peng Hsueh-Ju Liu Yen-Ku Wu

Published in: Chemistry, an Asian journal (2024)

Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.

Keyphrases

electron transfer
molecular dynamics
ionic liquid
biofilm formation
molecularly imprinted
escherichia coli
cystic fibrosis
life cycle