Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus.

Fatma I AlbeladiMostafa M MostafaMohamed A ZayedHazem Atta

Published in: International journal of general medicine (2022)

Our results showed that the genetic ability to combat oxidative stress may play a major role in DN pathogenesis in Saudi type II DM patients. These polymorphisms in antioxidant enzyme-encoding genes could be used as independent genetic markers for the construction of risk prediction models for kidney-related complications in type II DM patients.

Keyphrases

oxidative stress
end stage renal disease
ejection fraction
genome wide
chronic kidney disease
newly diagnosed
diabetic nephropathy
prognostic factors
gene expression
dna damage
dna methylation
copy number
transcription factor
skeletal muscle
weight loss
diabetic rats
genome wide identification