Malignant tumours of the uterus and ovaries with Mullerian and germ cell or trophoblastic components have a somatic origin and are characterised by genomic instability.

Andres Martin AcostaLynette M ShollPaola D CinBrooke E HowittChristopher N OtisMarisa R Nucci

Published in: Histopathology (2020)

Comparison of paired samples supports that the YST and trophoblastic tumour components of MMGC/T have a somatic origin and often show numerous copy-number variants, suggestive of underlying genomic instability.

Keyphrases

copy number
germ cell
mitochondrial dna
genome wide
dna methylation
gene expression