Patent landscape for discovery of promising acyltransferase DGAT and MGAT inhibitors.
Vishal P ZambreShamali M KhamkarDnyaneshwar D GavhaneSagar C KhedkarMonali R ChavanMadhuri M PandeySonali B SanapRajesh B PatilSanjay D SawantPublished in: Expert opinion on therapeutic patents (2020)
DGAT and MGAT inhibitors are now gaining significant importance in the treatment of metabolic diseases. Fused heterocycles with a combination of aromatic and aliphatic hydrophobic substituents could offer more potent DGAT and MGAT inhibitors. Previously reported chemical scaffolds and their DGAT and MGAT inhibitory activity could be employed as an input for some in silico studies to discover novel, potent and safe DGAT and MGAT inhibitors.
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