Configuration of active site segments in lytic polysaccharide monooxygenases steers oxidative xyloglucan degradation.
Peicheng SunChristophe V F P LaurentStefan ScheiblbrandnerMatthias FrommhagenDimitrios KouzounisMark G SandersWillem J H van BerkelRoland LudwigMirjam A KabelPublished in: Biotechnology for biofuels (2020)
The detailed characterization of XG degradation products released by LPMOs reveal a correlation between the configuration of active site segments and mode-of-action of LPMOs. In particular, oxidative XG-active LPMOs, which are tolerant and intolerant to XG substitutions are structurally and phylogenetically distinguished from XG-inactive LPMOs. This study contributes to a better understanding of the structure-function relationship of AA9 LPMOs.
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