Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury.
Yabin JiYiman ChenXixi TanXiaowen HuangQiang GaoYinzhong MaShilun YangMeifang YinMin YuCheng FangYu WangZhu ShiJunlei ChangPublished in: CNS neuroscience & therapeutics (2023)
Our study reveals the key molecular signatures of brain endothelial reperfusion injury and provides potential therapeutic targets for the treatment of brain microvascular injury after reperfusion therapy in ischemic stroke.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- resting state
- white matter
- acute myocardial infarction
- blood brain barrier
- brain injury
- acute ischemic stroke
- functional connectivity
- endothelial cells
- single cell
- genome wide
- stem cells
- single molecule
- gene expression
- atrial fibrillation
- rna seq
- combination therapy
- acute coronary syndrome
- bone marrow
- cell therapy