Management of Acute Myeloid Leukemia (AML) in Older Patients.
Maya AbdallahZhuoer XieAudrey ReadyDharmini ManognaJason H MendlerKah Poh LohPublished in: Current oncology reports (2020)
In lieu of using chronological age to determine fitness, we highlight the importance of standardized fitness assessments using geriatric assessments. Next, we review intensive and lower-intensity treatment options in the upfront setting. We focus on multiple newly approved medications, including venetoclax, midostaurin, CPX-351, gemtuzumab, glasdegib, enasidenib, and ivosidenib, and their specific indications. Lastly, we briefly discuss supportive care of older adults with AML. Outcomes of older adults with AML remain poor; fortunately, there are many new promising treatment options. Personalized treatment plans based on patient- and disease-specific factors are essential to the care of older adults with AML.
Keyphrases
- acute myeloid leukemia
- physical activity
- allogeneic hematopoietic stem cell transplantation
- community dwelling
- middle aged
- healthcare
- palliative care
- body composition
- quality improvement
- case report
- high intensity
- pain management
- health insurance
- type diabetes
- metabolic syndrome
- combination therapy
- drug administration