Neural and Onconeural Autoantibodies and Blood-Brain Barrier Disruption Markers in Patients Undergoing Radiotherapy for High-Grade Primary Brain Tumour.
Katarzyna HojanKrystyna AdamskaAgnieszka LewandowskaDanuta ProcykEwa LeporowskaKrystyna OsztynowiczSlawomir MichalakPublished in: Diagnostics (Basel, Switzerland) (2024)
The findings of this study show that a humoral immune response is common in patients undergoing RT for brain cancer. This response appears to be non-organ specific but rather directed against nucleosome antigens, but onconeural antibodies were uncommon, suggesting a low risk of a neurological paraneoplastic syndrome. Our data suggested that radiotherapy may not affect BBB integrity, but larger studies are needed to better characterise the pathophysiological effects of RT.
Keyphrases
- blood brain barrier
- cerebral ischemia
- patients undergoing
- immune response
- high grade
- early stage
- locally advanced
- resting state
- dendritic cells
- white matter
- radiation therapy
- papillary thyroid
- radiation induced
- low grade
- systemic lupus erythematosus
- squamous cell
- electronic health record
- toll like receptor
- subarachnoid hemorrhage
- machine learning
- inflammatory response
- multiple sclerosis
- rectal cancer
- childhood cancer
- data analysis
- brain injury