Misfolded α-Synuclein Assessment in Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.

Alex IranzoAngela MammanaAmaia Muñoz-LopetegiSofia DellavalleGerard MayàMarcello RossiMonica SerradellSimone BaiardiAurora ArquerosCorinne QuadaltiAndrés PerissinottiEdoardo RuggeriJoan Santamaria CanoCarles GaigPiero Parchi

Published in: Neurology (2023)

This study provides Class III evidence that RT-QuIC detected misfolded α-synuclein in the skin and CSF distinguishes patients with IRBD from controls.

Keyphrases

soft tissue
wound healing
physical activity
sleep quality
cerebrospinal fluid
depressive symptoms