No convincing association between genetic markers and respiratory symptoms: results of a GWA study.

Xiang ZengJudith M VonkKim de JongXijin XuXia HuoH Marike Boezen

Published in: Respiratory research (2017)

Given that only 1 out of 50 SNPs showed significant replication (i.e. 2%) we conclude that we did not find a convincing association between genetic markers and respiratory symptoms. Since, environmental exposures are important risk factors for respiratory symptoms, the next step is to perform a genome-wide interaction (GWI) study to identify genetic susceptibility loci for respiratory symptoms in interaction with known harmful environmental exposures.

Keyphrases

genome wide
dna methylation
copy number
air pollution
respiratory tract
gene expression
human health
risk assessment
depressive symptoms
climate change
genome wide association