Characterization of Drug-Drug Interactions on the Pharmacokinetic Disposition of Busulfan in Pediatric Patients during Hematopoietic Stem Cell Transplantation Conditioning.

To the best of our knowledge, this is the largest single center study of busulfan in children and the first to quantify the maturation effect of both clearance and volume. This study could not demonstrate a difference in busulfan clearance when comparing patients who received medications that alter the GST, CYP3A4, or CYP2C9 pathway to those who did not.