Cystic Fibrosis Transmembrane Conductance Regulator Protein Modulators in Children and Adolescents with different CF Genotypes - Systematic Review and Meta-Analysis.

Alaa Hassan Yousif HamdanFaiza ZakariaMaria Kezia Lourdes PormentoOdunayo Susan LawalAdaugo OpiegbeSamina ZahidPrathima GuntipalliUjala NasrSyed Asad Hasan Rizvi

Published in: Current reviews in clinical and experimental pharmacology (2023)

In children aged ≥ 6 y old and adolescents with F508del_CFTR mutation, Elexacaftor-Tezacaftor-Ivacaftor tend to be more effective than first-generation therapy, demonstrating promising results by exhibiting significant improvement in lung function, body weight, and respiratory-related quality of life.

Keyphrases

cystic fibrosis
lung function
body weight
pseudomonas aeruginosa
young adults
small molecule
physical activity
protein protein
transcription factor
binding protein
amino acid
stem cells
chronic obstructive pulmonary disease
air pollution
respiratory tract
mesenchymal stem cells
bone marrow
drug induced