MLH1 Loss in Primary Prostate Cancer.
Sanaz Nourmohammadi AbadchiLaura A SenaEmmanuel S AntonarakisColin C PritchardJames R EshlemanEric Quentin KonnickStephen J SalipanteEugene ShenderovTamara L LotanPublished in: JCO precision oncology (2023)
These cases highlight the challenges in identifying MLH1-deficient prostate cancers using standard MSI testing and commercial sequencing panels, and support the utility of immunohistochemical assays and LMR- or sequencing-based MSI testing for detection of MMRd prostate cancers.