Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint.
Ricardo Grieshaber-BouyerTarik ExnerNicolaj S HackertFelix Andreas RadtkeScott A JelinskyOlha HalyabarAlexandra WactorElham KarimizadehJoseph BrennanJorge SchettiniHelena JonssonDeepak A RaoLauren A HendersonCarsten Müller-TidowHanns-Martin LorenzGuido WabnitzJames A LedererAngela HadjipanayisPeter A NigrovicPublished in: Annals of the rheumatic diseases (2022)
Circulating neutrophils from patients with arthritis resemble those from healthy controls, but joint fluid cells exhibit a network of changes, conserved across species, that implicate IFN-γ response and ageing as complementary drivers of the synovial fluid neutrophil phenotype.