A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study.
Ira DriscollBeverly M SnivelyMark A EspelandSally A ShumakerStephen R RappJoseph S GoveasRamon L CasanovaJean Wactawski-WendeJoAnn E MansonRebecca RossomJanet BrooksDena G HernandezAndrew B SingletonSusan M ResnickPublished in: International journal of geriatric psychiatry (2019)
Our results in older women provide supporting evidence that the APOE/TOMM40 genes confer dementia risk and extend these findings to COMT, BDNF, and KIBRA. Our findings may lead to a better understanding of the role these genes play in cognition and cognitive impairment.
Keyphrases
- cognitive impairment
- postmenopausal women
- mild cognitive impairment
- genome wide
- bone mineral density
- public health
- cognitive decline
- multiple sclerosis
- working memory
- mental health
- dna methylation
- adipose tissue
- body composition
- white matter
- middle aged
- transcription factor
- pregnancy outcomes
- genome wide analysis
- insulin resistance
- stress induced
- community dwelling
- bioinformatics analysis