Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.
Madeleine CarbonneauYi LiBrenton R PrescottChunyu LiuTianxiao HuanRoby JoehanesJoanne M MurabitoNancy Heard- CostaVanessa XanthakisDaniel LevyJiantao MaPublished in: Journal of the American Heart Association (2024)
DNA methylation-based epigenetic age scores mediate the associations between the LE8 score and incident CVD, CVD-specific mortality, and all-cause mortality, particularly in individuals with higher genetic predisposition for older epigenetic age.