Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice.
Sophie A H JacobsEveline GartDebby VreekenBart A A FranxLotte WekkingVivienne G M VerweijNicole WormsMarieke H SchoemakerGabriele GrossMartine C MorrisonRobert KleemannIlse A C ArnoldussenAmanda J KiliaanPublished in: Nutrients (2019)
At young age, male mice are more susceptible to the detrimental effects of HFD than female mice. This study emphasizes the importance of sex-specific differences in obesity, liver pathology, and brain function.
Keyphrases
- high fat diet induced
- high fat diet
- insulin resistance
- adipose tissue
- metabolic syndrome
- weight loss
- resting state
- white matter
- type diabetes
- functional connectivity
- high glucose
- cerebral ischemia
- diabetic rats
- weight gain
- multiple sclerosis
- skeletal muscle
- drug induced
- middle aged
- body mass index
- oxidative stress
- subarachnoid hemorrhage
- low density lipoprotein