Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.

Venhar Cınar Bulent Ozpolat Ahsen Guler Nursultan Nurdinov Bulent Ozpolat

Published in: Breast cancer (Tokyo, Japan) (2022)

Our findings suggest for the first time that the 5-HT7 receptor promotes FOXM1, eEF2K and cyclin D1 signaling to support TNBC cell proliferation; thus, inhibition of 5-HT7 receptor/FOXM1 signaling may be used as a potential therapeutic strategy for targeting TNBC. 5-HT induces cell proliferation of TNBC cells through 5-HT7 receptor signaling. Also, genetic and pharmacological inhibition of 5-HT7 by RNAi (siRNA) and metergoline HTR7 antagonist, respectively inhibits FOXM1 oncogenic transcription factor and suppresses TNBC cell proliferation.

Keyphrases

cell proliferation
induced apoptosis
cell cycle arrest
transcription factor
cell cycle
signaling pathway
pi k akt
prognostic factors
cancer therapy
cell death
oxidative stress
gene expression
drug delivery
copy number