Heterogenous CD8+ T Cell Maturation and 'Polarization' in Acute and Convalescent COVID-19 Patients.
Igor V KudryavtsevNatalia A ArsentievaZoia R KorobovaDmitry V IsakovArtem A RubinshteinOleg K BatsunovIrina V KhamitovaRaisa N KuznetsovaTikhon V SavinTatiana V AkishevaOksana V StanevichAleksandra A LebedevaEvgeny A VorobyovSnejana V VorobyovaAlexander N KulikovMaria A SharapovaDmitrii E PevtsovAreg A TotolianPublished in: Viruses (2022)
We described an abnormal CD8+ T cell profile in COVID-19 convalescents, which resulted in lower frequencies of effector subsets (TEMRA and Tc1), higher senescent state (upregulated CD57 on 'naïve' and memory cells), and higher frequencies of CD8+ T cell subsets expressing lung tissue and mucosal tissue homing molecules (Tc2, Tc17, and Tc17.1). Thus, our data indicate that COVID-19 can impact the long-term CD8+ T cell immune response.
Keyphrases
- sars cov
- coronavirus disease
- immune response
- induced apoptosis
- peripheral blood
- liver failure
- dendritic cells
- respiratory syndrome coronavirus
- cell cycle arrest
- working memory
- respiratory failure
- regulatory t cells
- drug induced
- toll like receptor
- intensive care unit
- artificial intelligence
- cell proliferation
- mechanical ventilation