Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals.
Marcel Seungsu WooCécile TissotJuan Lantero-RodriguezAnniina SnellmanJoseph TherriaultNesrine RahmouniArthur C MacedoStijn ServaesYi-Ting WangJaime Fernandez AriasSeyyed Ali HosseiniMira ChamounFiroza Z LussierAndrea L BenedetNicholas J AshtonThomas K KarikariGallen Triana-BaltzerHartmuth C KolbJenna StevensonChristina MayerEliane KobayashiGassan MassarwehManuel A FrieseTharick A PascoalSerge GauthierHenrik ZetterbergKaj BlennowPedro Rosa-NetoPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
We found that in a cohort without pre-selection pTau-181, pTau-217, and NTA-tau showed the highest association with tau PET positivity. We found that in Aβ+ individuals pTau-217 and NTA-tau showed the highest association with tau PET positivity. Combining pTau-217 and NTA-tau resulted in the strongest agreement with the tau PET-based classification.