Impact of a submaximal mono-articular exercise on the skeletal muscle function of patients with sickle cell disease.

Etienne GouraudPhilippe ConnesAlexandra Gauthier-VasserotCamille FaesSalima MerazgaSolène PoutrelCéline RenouxCamille BoissonPhilippe JolyYves BertrandArnaud HotGiovanna CannasChristophe A Hautier

Published in: European journal of applied physiology (2021)

These results show skeletal muscle dysfunction during exercise in SCD patients, and suggest different fatigue aetiology between SS and SC. The changes in EMG signal and oxygenation kinetics during exercise suggest that the greater skeletal muscle fatigue occurring in SCD patients would be rather due to intramuscular alterations modifications than decreased tissue oxygenation. Moreover, SS patients exhibit greater muscle fatigability than SC.

Keyphrases

skeletal muscle
end stage renal disease
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
oxidative stress
type diabetes
high intensity
metabolic syndrome
body composition
patient reported
sleep quality
blood flow