Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis.
Mirjam PodgoricaElsa DrivetJonas Krag VikenAlyssa RichmanJohanne VestbøstadPeter SzodorayAnn Kristin KvamHilde Skuterud WikGeir Erland TjønnfjordLudvig A MuntheSeth E FrietzeHilde SchjervenPublished in: European journal of haematology (2024)
We demonstrate that RNA-seq is an effective tool for precision medicine in B-ALL by providing comprehensive molecular profiling of leukemia cells, identifying subtype and oncogenic lesions, and stratifying patients for appropriate therapy.
Keyphrases
- rna seq
- single cell
- acute lymphoblastic leukemia
- end stage renal disease
- induced apoptosis
- newly diagnosed
- copy number
- ejection fraction
- chronic kidney disease
- prognostic factors
- acute myeloid leukemia
- single molecule
- peritoneal dialysis
- bone marrow
- transcription factor
- cell cycle arrest
- oxidative stress
- mesenchymal stem cells
- cell proliferation
- cell death
- patient reported
- signaling pathway
- dna methylation
- childhood cancer
- endoplasmic reticulum stress