Are insulin-resistance and oxidative stress cause or consequence of aging.
Sylwia Dzięgielewska-GęsiakDorota StołtnyAlicja BrożekMałgorzata Muc-WierzgońSylwia Dziegielewska-GesiakPublished in: Experimental biology and medicine (Maywood, N.J.) (2020)
Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.
Keyphrases
- oxidative stress
- insulin resistance
- type diabetes
- high fat diet
- metabolic syndrome
- adipose tissue
- glycemic control
- skeletal muscle
- polycystic ovary syndrome
- diabetic rats
- ischemia reperfusion injury
- anti inflammatory
- dna damage
- cardiovascular disease
- middle aged
- high fat diet induced
- induced apoptosis
- community dwelling
- risk factors
- healthcare
- palliative care
- heat shock
- drinking water
- nitric oxide
- signaling pathway
- risk assessment
- cardiovascular events
- endoplasmic reticulum stress
- social media
- amyotrophic lateral sclerosis