Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers.

Herein we report the design and synthesis of a terphen[ n ]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.