Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI.
Derek J ErstadMozhdeh SojoodiMartin S TaylorVeronica Clavijo JordanChristian T FarrarAndrea L AxtellNicholas J RotileChloe JonesKatherine A Graham-O'ReganDiego S FerreiraTheodoros P MichelakosFilippos KontosAkhil ChawlaShen LiSarani GhoshalYin-Ching Iris ChenGunisha AroraValerie HumbletVikram DeshpandeMotaz QadanNabeel BardeesyCristina R FerroneMichael LanutiKenneth K TanabePeter CaravanBryan C FuchsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
In humans, post-chemoradiation tumor fibrosis is associated with OS and DFS. In mice, our MR findings indicate that translation of collagen molecular MRI with CM-101 to humans might provide a novel imaging technique to monitor fibrotic response to therapy to assist with prognostication and disease management.
Keyphrases
- contrast enhanced
- rectal cancer
- magnetic resonance imaging
- locally advanced
- systemic sclerosis
- idiopathic pulmonary fibrosis
- high resolution
- computed tomography
- diffusion weighted imaging
- wound healing
- squamous cell carcinoma
- stem cells
- radiation therapy
- skeletal muscle
- mass spectrometry
- tissue engineering
- cell therapy
- smoking cessation
- wild type
- fluorescence imaging