Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle.
Jennyffer SouzaRodrigo A Foganholi da SilvaDébora da Luz SchefferRafael PenteadoAlexandre SolanoLeonardo BarrosHenning BuddeAndres TrostchanskyAlexandra LatiniPublished in: Antioxidants (Basel, Switzerland) (2022)
Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle.
Keyphrases
- oxidative stress
- skeletal muscle
- anti inflammatory
- signaling pathway
- nuclear factor
- diabetic rats
- primary care
- healthcare
- insulin resistance
- resting state
- white matter
- physical activity
- induced apoptosis
- epithelial mesenchymal transition
- transcription factor
- single cell
- functional connectivity
- adipose tissue
- stem cells
- high intensity
- immune response
- cell therapy
- quality improvement
- inflammatory response
- brain injury