A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation.

Ling HuSi-Si ChenHui ZhangJing-Jing ChaoZhen-Zhen PengGuo-Jiang MaoLiufang HuJuan OuyangAnjie MinChun-Yan Li

Published in: Chemical communications (Cambridge, England) (2024)

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO - in living cells, image ONOO - in paw edema mice and evaluate anti-inflammatory drugs.

Keyphrases

fluorescent probe
living cells
anti inflammatory drugs
high fat diet induced
photodynamic therapy
high resolution
type diabetes
emergency department
insulin resistance
machine learning
adipose tissue
fluorescence imaging