L(59) TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice.
Mitsuko HaraIkuyo InoueYuta YamazakiAkiko KiritaTomokazu MatsuuraScott L FriedmanDaniel B RifkinSoichi Kojima
Published in: Fibrogenesis & tissue repair (2015)
L(59) LAP-DPs reflect PLK-dependent TGF-β activation and the increase in αSMA-positive activated HSCs in liver injury, thereby serving as a novel blood biomarker for liver fibrogenesis.