Bio-evaluation of Poly-Lactate co-Glycolic Acid (PLGA) nanoparticles loaded with radio-labeled rifampicin.

Significant difference in PK parameters and bio-distribution of nanoparticles in spleen and lymph nodes with maximum deposition were observed in large intestine. Nanoparticle distribution pattern may be advantageous for the treatment of intestinal or lymph node TB and has the potential to result in a lower dose of rifampicin nanoformulation for the treatment of pulmonary TB.